Agenda

Agenda

All times listed are Eastern Daylight Time.

All talks will be mainly pre-recorded with live question/answer periods. Please note that the agenda is subject to change.

Day 1: Tuesday, June 22, 2021

TimeTitle/Topic Event
8:30 - 8:45 AMConference Opens – Welcome
 Organizer: Tom Rutkowski
 Co-organizer: Carolyn Sevier
8:45 -10:00 AM
 		EMBO Keynote Lecture
 Jonathan Weissman
Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients
10:00 -10:15 AMLive Q&A with the Keynote
10:15 -11:55 AMSession I: Translational Approaches
 Moderators: Pedro Carvalho and Xi Chen
10:15 – 10:35 AMSpeaker 1: Fumihiko Urano
Endoplasmic Reticulum: A Primary Therapeutic Target for Wolfram syndrome, Diabetes, and Retinal Degeneration
10:35 - 10:55 AMSpeaker 2: Anne Bertolotti
eIF2 phosphorylation: Ups and downs
10:55 – 11:15 AMSpeaker 3: Luke Wiseman
Pharmacologic Targeting of the Unfolded Protein Response
11:15 – 11:35 AMSpeaker 4: Chris Wooddell
RNAi therapeutic to prevent and reverse ER accumulation of Z-alpha-1 antitrypsin
11:35 – 11:55 AMLive Q&A
11:55 - 12:15 PMBreak
12:15 – 1:15 PMMeet the Experts:
Luke Wiseman, Xi Chen, Susan Fink, and Anne Bertolotti 
Moderator: Tom Rutkowski
1:15 - 2:15 PMPoster Session 1
2:15 – 5:10 PMSession II: ER Biogenesis
 Moderators: Susan Ferro-Novick and Abby Buchwalter
2:15 – 2:35 PMSpeaker 1: Chris Nicchitta
RNA Localization and Translation on the ER: Models and Mechanisms
2:35 – 2:55 PMSpeaker 2: Susan Shao
Structural insights into metazoan pre-targeting GET complexes
2:55 – 3:05 PMShort Talk 1
 Smita Yadav
An ER Kinase that Catalyzes the Dynamic Tethering of ER to Microtubules
3:05 – 3:15 PMShort Talk 2
Ahmad Jomaa
Mechanism of co-translational nascent chain sorting and targeting to the endoplasmic reticulum by NAC and SRP
3:15 - 3:35 PMLive Q&A
3:35 - 3:55 PMSpeaker 3: Robert Keenan
An ER translocon for multi-pass membrane protein biogenesis
3:55 – 4:15 PMSpeaker 4: Shu-ou Shan
Fidelity of cotranslational protein targeting to the ER
4:15 – 4:25 PMShort Talk 3
 Jacob Culver
Deubiquitinases USP20/33 promote the biogenesis of tail-anchored membrane proteins
4:25 - 4:35 PMShort Talk 4
 Elena Ivanova
Dissecting protein localization signals with deep mutational scanning
4:35 - 4:45 PMShort Talk 5
Haddas Saad
Protein dynamics from the ER to the ERQC and back
4:45 – 5:10 PMLive Q&A
5:10 - 5:20 PMConclusion - End of Day One

 

Day 2: Wednesday, June 23, 2021

TimeTitle/Topic Event
8:30 - 8:40 AMConference Opens – Welcome Day 2
 Organizer: Tom Rutkowski
8:40 -12:05 PMSession III: ER Quality Control
Moderators: Liz Miller and Guillaume Thibault
8:40 – 9:00 AMSpeaker 1: Kaz Nagata
Quality control of procollagen in the ER by collagen-specific molecular chaperone Hsp47
9:00 - 9:20 AMSpeaker 2: Linda Hendershot
Mapping BiP co-chaperone binding sequences in Surfactant Protein C provides insights into BRICHOS domain function and disease-associated mutations
9:20 – 9:40 AMSpeaker 3: Pedro Carvalho
Quality control of membrane proteins at the ER
9:40 - 10:00 AMSpeaker 4: Ineke Braakman
Intramolecular quality control
10:00 – 10:20 AMLive Q&A
10:20 – 10:40 AMSpeaker 5: James Olzmann
Lipid droplet proteome remodeling and ER-associated degradation
10:40 – 11:00 AMSpeaker 6: Jeff Brodsky
Choosing your poison: The targeting of misfolded proteins for ERAD versus post-ER degradation
11:00 – 11:20 AMSpeaker 7: Sonya Neal
Rhomboid pseudo amprotease Dfm1 ERADicates multi-spanning membrane substrates from the ER
11:20 – 11:30 AMShort Talk 6
Prasanna Satpute-Krishnan
Competition for calnexin binding regulates the turnover of misfolded GPI-anchored proteins
11:30 – 11:40 AMShort Talk 7
 Ilaria Fregno
N-glycan processing dictates proteasomal or lysosomal clearance of misfolded proteins from the ER
11:40 – 12:05 PMLive Q&A
12:05 – 12:30 PMBreak
12:30 – 1:45 PMCareer Development Session
Job paths outside postdoc-to-research university PI?
Moderator: Carolyn Sevier
Participants:
 Will Prinz
 Chris Wooddell
 VJ Rubenstein
1:45 - 2:45 PMPoster Session 2
2:45 – 4:55 PMSession IV: Organelle Communication
Moderators: Linda Hendershot and Lars Plate
2:45 – 3:05 PMSpeaker 1: Liz Miller
A biophysical basis for sorting stringency into COPII vesicles
3:05 – 3:25 PMSpeaker 2: William Prinz
Contact sites and GPI anchor synthesis
3:25 – 3:35 PMShort Talk 8
 Tino Pleiner
WNK1 is an assembly factor for the human ER membrane protein complex
3:35 – 3:50 PMLive Q&A
3:50 – 4:10 PMSpeaker 3: Gyuri Hajnoczky
ER-mitochondrial contacts and local signaling by Ca2+ and ROS
4:10 – 4:30 PMSpeaker 4: Susan Ferro-Novick
A role for a COPII coat subunit in ER autophagy
4:30 – 4:40 PM              Short Talk 9
 Ilaria Sorrentino
A redox ER-mitochondria crosstalk sustains oxidative folding
4:40 – 4:55 PMLive Q&A
4:55 - 5:15 PMConclusion - End of Day Two

 

Day 3: Thursday, June 24, 2021

TimeTitle/Topic Event
8:30 - 8:40 AMConference Opens – Welcome Day 3
 Organizer: Tom Rutkowski
8:40 - 12:25 PMSession V: Metabolic and Infectious Diseases
Moderators: James Olzmann and Susan Shao
8:40 – 9:00 AMSpeaker 1: Billy Tsai
How ER-phagy degrades mutant proinsulins to rectify a diabetic syndrome
9:00 - 9:20 AMSpeaker 2: Susan Fink
Unfolding the roles of ER stress in viral infection
9:20 – 9:40 AMSpeaker 3: Ying Maggie Chen
Endoplasmic Reticulum Dyshomeostasis and Kidney Disease
9:40 – 9:50 AMShort Talk 10
Chien-Wen Chen
Adaptive reprogramming of pancreatic beta-cells to chronic ER stress
9:50 – 10:00 AMShort Talk 11
 Mariska Simpson
IRE1a directly binds the cholera toxin subdomain A1
10:00 – 10:25 AMLive Q&A
10:25 – 10:40 AMBreak
10:40 – 11:00 AMSpeaker 4: Gisou van der Gout
Palmitoylation in SARS-CoV biogenesis in the early secretory pathway
11:00 – 11:20 AMSpeaker 5: Emilyn Alejandro
O-GlcNAc signaling, the sweet side regulation of ER stress and insulin processing in pancreatic beta-cells
11:20 – 11:40 AMSpeaker 6: Lars Plate
Comparative interactomics of coronavirus nonstructural proteins identifies shared and unique ER-mitochondrial host cell dependencies
11:40 – 11:50 AMShort Talk 12
Rakesh Ganji
Regulation of Endoplasmic Reticulum and Mitochondria contact sites dynamics by p97-UBXD8 complex via lipid metabolism
11:50 – 12:00 PMShort Talk 13
 Amit Joshi
Formation of nascent lipid droplets at specialized ER subdomains
12:00 – 12:25 PMLive Q&A
12:25 – 12:40 PMBreak
12:40 – 1:40 PMMeet the Experts
Jeff Brodsky, Liz Miller, Susan Ferro-Novick, and Chris Nicchitta
Moderator: Tom Rutkowski
1:40 - 1:50 PMBreak
1:50 – 5:05 PMSession VI: UPR Signaling, Cell Fate, and Cancer
Moderators: Carolyn Sevier and Sonya Neal (to be confirmed)
1:50 – 2:10 PMSpeaker 1: Rebecca Taylor
Inter-tissue UPR Activation: How Neuronal Signaling Promotes Organismal Resilience
2:10 – 2:30 PMSpeaker 2: Randal Kaufman
The UPR transducer ATF6 drives fatty liver disease progression to carcinoma
2:30 – 2:50 PMSpeaker 3: Abby Buchwalter
A long strange trip: dynamic trafficking of the inner nuclear membrane protein emerin to the lysosome
2:50 – 3:00 PMShort Talk 14
 Luke Perera
Post-translational regulation of BiP by FICD-mediated AMPylation and deAMPylation
3:00 – 3:10 PM              Short Talk 15
 Weihan Li
Regulating ER protein homeostasis by differentially processing mRNAs
3:10 – 3:35 PMLive Q&A
3:35 – 3:45 PMBreak
3:45 – 4:05 PMSpeaker 4: Shannon Elf
Characterizing and targeting the unfolded protein response in calreticulin-mutated myeloproliferative neoplasms
4:05 – 4:25 PMSpeaker 5: Xi Chen
Targeting the Unfolded Protein Response to reverse therapy resistance
4:25 – 4:35 PMShort Talk 16
 Ojore Oka
Activation of the UPR sensor ATF6 is regulated by its redox-dependent dimerisation
4:35 – 4:45 PMShort Talk 17
 Thorsten Hoppe
ER Quality Control Is Mediated by ER-Associated RNA Silencing (ERAS)
4:45 – 5:05 PMLive Q&A
5:05 - 5:30 PMConclusion - End of Day Three
 Organizer: Tom Rutkowski
 Co-organizer: Carolyn Sevier