The Steroid Hormones and Receptors in Health and Disease Conference - Jointly held with the International Committee on Rapid Responses to Steroid Hormones (RRSH)
Agenda
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***Please note that the times presented are in Central Time (CT).
Day 1: Tuesday, May 25, 2021
Time ***Central Time (CT) | Event |
8:45 am – 9:00 am | Welcome and Introductions: Dan Frigo (University of Texas MD Anderson Cancer Center) & Eric Prossnitz (University of New Mexico) |
9:00 am – 9:30 am | Keynote Address: Donald McDonnell (Duke University School of Medicine) “If We Knew Then What We Know Now, What We Would Have Done Differently to Exploit Nuclear Receptors as Drug Targets” |
9:30 am – 9:45 am | Discussion |
9:45 am – 12:00 pm | Nuclear Steroid Receptor Regulation of Macrometabolism Discussion Leaders: Gian Paolo Rossi (University of Padova) & Sayeepriyadarshini Anakk (University of Illinois) |
9:45 am – 10:00 am | Adriana Maggi (University of Milan) “Liver Estrogen Receptors and Metabolic Function” |
10:00 am – 10:15 am | Carolyn Cummins (University of Toronto) “Glucocorticoid-induced obesity is mitigated by LXRβ in mice” |
10:15 am – 10:30 am | Andrea Hevener (UCLA) “Estrogen Regulation of Insulin Actions” |
10:30 am – 10:45 am | Joint Discussion |
10:45 am – 11:00 am | Break |
11:00 am – 11:15 am | Sheng Wu (Johns Hopkins University) “Nuclear and Extranuclear Hepatic Androgen Receptor Action in Insulin Resistance in Females” |
11:15 am – 11:30 am | Brian Feldman (UCSF) “The glucocorticoid receptor links food consumption to adipocyte stem cell activity” |
11:30 am – 11:45 am | Wen Xie (University of Pittsburgh) “Sex and Tissue-specific Roles of Estrogen Sulfotransferase and Steroid Sulfatase in Energy Metabolism” |
11:45 am – 12:00 pm | Warren Thomas (Royal College of Surgeons in Ireland) “Aldosterone regulation of renal Na+ reabsorption via novel protein kinase D isoforms” |
12:00 pm – 12:15 pm | Joint Discussion |
12:15 pm – 1:00 pm | Break |
12:15 pm – 1:00 pm | ROUNDTABLE DISCUSSION (to take place on the virtual platform): Science Policy Fellowships – learn about FASEB and FASEB member society-sponsored fellowship opportunities for students and postdocs interested in pursuing a career in science policy. Will include discussion about upcoming openings for U.S. citizens as well as non-citizens, skills that are transferable, and tips for applicants. HOST: Yvette Seger, PhD, FASEB Director of Science Policy |
1:00 pm – 3:15 pm | Clinical Aspects of Therapies Targeting Steroid Hormone Receptors Discussion Leaders: Jay Gertz (Huntsman Cancer Institute/University of Utah School of Medicine) & Martin Wehling (University of Heidelberg) |
1:00 pm – 1:15 pm | Iris Jaffe (Tufts University) “Vascular MR: Evolutionary Mediator of Wound Healing Turned Harmful by Our Modern Lifestyle” |
1:15 pm – 1:30 pm | James Pru (University of Wyoming) “PGRMC1 and PGRMC2 Functions in Uterine Physiology and Disease” |
1:30 pm – 1:45 pm | Paul Davis (Albany Medical College, NanoPharmaceuticals LLC) “Targeting non-genomic thyroid signaling for the treatment of glioblastoma” |
1:45 pm – 2:00 pm | Joint Discussion |
2:00 pm – 2:15 pm | Break |
2:15 pm – 2:30 pm | Wilbert Zwart (Netherlands Cancer Institute) “Cistromics in Clinical Trials: From Markers to Mechanisms” |
2:30 pm – 2:45 pm | Mathieu Lupien (University of Toronto) “Epigenetics of Hormone-dependent Cancer” |
2:45 pm – 3:00 pm | Lightning round of selected 3-minute poster abstracts: Florian Le Billan (University of Toronto) "The nuclear receptor coregulator ARGLU1 potentiates glucocorticoid-induced insulin resistance and type 2 diabetes" Alicia Arredondo Eve (University of Illinois at Urbana-Champaign) "Identification of diagnostic plasma biomarkers of coronary microvascular disease in postmenopausal women using machine learning methods" Ximena Calle Chalco (Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical & Pharmaceutical Sciences, University of Chile) "17-β estradiol regulates MUL1 and cardiomyocyte hypertrophy" Innocence Harvey (Pennington Biomedical Research Center (LSU)) "Artemisia scoparia Attenuates Glucocorticoid-Induced Lipolysis" Jia Xu Li (University of Toronto) "Disruption of Adipose Tissue Metabolism by Glucocorticoids is Attenuated with LXRβ Antagonism" |
3:00 pm – 3:15 pm | Joint Discussion |
3:15 pm – 3:30 pm | Break |
3:45 pm – 5:00 pm | Poster Session |
Day 2: Thursday, May 27, 2021
Time ***Central Time (CT) | Event |
9:30 am – 9:45 am | Day Three: Welcome |
9:45 am – 12:00 pm | Novel Functions of Steroid Receptors in Cancer Discussion Leaders: Christy Hagan (University of Kansas Medical Center) & Stephen Hammes (University of Rochester Medical Center) |
9:45 am – 10:00 am | Rosamaria Lappano (University of Calabria) "New findings on the action of GPER in breast cancer” |
10:00 am – 10:15 am | Carol Lange (University of Minnesota) “PR and GR - functionally redundant signaling properties in stemness” |
10:15 am – 10:30 am | Lightning round of selected 3-minute poster abstracts Anasuya Das Gupta (University of Illinois, Urbana Champaign) "Mechanisms by which 27-Hydroxycholesterol modulates Extracellular Vesicle biogenesis" Sarah El Kharraz (KU Leuven, Molecular and Cellular Medicine) "Dimerization of the ligand-binding domain is crucial for normal functioning of the androgen receptor in mice" Asmaa El-Kenawi (Moffitt Cancer Center) "Tumor - macrophage metabolic interactions regulate androgen biosynthesis to induce therapeutic resistance in prostate cancer" Wanting Han (University of Massachusetts Boston) "CDK4/6 inhibitor enhances the tumor-suppressive activity of high-dose androgen in castration-resistant prostate cancer" Thu Truong (University of Minnesota) "PELP1/SRC-3-dependent regulation of metabolic PFKFB kinases drives therapy resistant ER+ breast cancer" |
10:30 am – 10:45 am | Joint Discussion |
10:45 am – 11:00 am | Break |
11:00 am – 11:15 am | Marina Holz (New York Medical College) “Crosstalk between mTOR and estrogen signaling” |
11:15 am – 11:30 am | Matt Sikora (University of Colorado, School of Medicine) “Unique Estrogen Receptor Biology Underlies Therapy Response and Resistance in Lobular Carcinoma” |
11:30 am – 11:45 pm | Scott Tomlins (Strata Oncology) “High-throughput "Omics" to Identify Driver Mutations and Gene Fusions in Cancer” |
11:45 pm – 12:00 pm | Joint Discussion |
12:00 pm – 1:00 pm | Break |
1:00 pm – 2:45 pm | Targeting Steroid Receptors: New Mechanisms Discussion Leaders: Donald DeFranco (University of Pittsburgh) & Ellis Levin (University of California- Irvine) |
1:00 pm – 1:15 pm | Elahe Mostaghel (Fred Hutchinson Cancer Center) “Adrenal androgens and AR axis inhibition in prostate cancer – mechanism of resistance and predictors of response” |
1:15 pm – 1:30 pm | Douglas Kojetin (Scripps Research-Florida) “Ligand-induced PPARγ repression made crystal clear with NMR spectroscopy” |
1:30 pm – 1:45 pm | Joint Discussion |
1:45 pm – 2:00 pm | Break |
2:00 pm – 2:15 pm | Edward Filardo (University of Iowa) “Dual specificity PROTACs that target plasma membrane and intracellular estrogen receptors” |
2:15 pm – 2:30 pm | John Katzenellenbogen (University of Illinois) “Unusual Effects of Estrogens Through Estrogen Receptor Beta and From Very Low Affinity Ligands” |
2:30 pm – 2:45 pm | Joint Discussion |
2:45 pm – 3:00 pm | Break |
3:00 pm – 4:45 pm | Nuclear Steroid Receptor/Metabolic Crosstalk Discussion Leaders: Kristy Brown (Weill Cornell Medicine) & Subhamoy Dasgupta (Roswell Park Comprehensive Cancer Center) |
3:00 pm – 3:15 pm | Ian Mills (Queens University Belfast) “AR-regulated Metabolism in Prostate Cancer” |
3:15 pm – 3:30 pm | Rebecca Riggins (Georgetown University) “ERR Metabolism in Breast Cancer, Metabolism in GBM” |
3:30 pm – 3:45 pm | Joint Discussion |
3:45 pm – 4:00 pm | Break |
4:00 pm – 4:15 pm | Giorgia Zadra (Institute of Molecular Genetics, National Research Council-Italy) “Modulation of intra-tumor lipid metabolism is a non-canonical approach to target AR receptor" |
4:15 pm – 4:30 pm | Erik Nelson (University of Illinois) “Cholesterol, ER and LXRs Functions in the Breast Cancer Metastatic Tumor Microenvironment” |
4:30 pm – 4:45 pm | Phil Shaul (UTSW) “Estrogen Receptor Signaling in Endothelium in Cardiometabolic Health and Disease” |
4:45 pm – 5:00 pm | Joint Discussion |
5:00 pm – 5:15 pm | Wrap-up by Conference Organizers |