The 2015 BioArt Winners

Scroll below for the winners of the 2015 BioArt Contest. For better viewing, click the images below to enlarge them.

Alice Dohnalkova

Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA

Research Focus: Soil ecology and microbes

In this electron scanning microcopy image, an intricately structured soil bacterium (yellow) can be seen making its home on the root surface of an Arabidopsis plant (purple and blue). Much remains to be learned about the plant root zone (rhizosphere) and the microbes living within it. A research campaign is working to expand our understanding of the presence and distribution of carbon within the root zone and how it impacts the diversity and function of the microbes present. The ultimate goal is to develop predictive models to enhance the production of bioenergy crops and mitigate the negative impacts of climate change. 

This image was created at the Department of Energy Office of Biological & Environmental Research Environmental Molecular Sciences Laboratory (EMSL). This national scientific user facility provides investigators around the country with access to cutting-edge technology and scientific instruments. The root zone campaign includes researchers at EMSL, the Pacific Northwest National Laboratory, the Joint Genome Institute, Brookhaven National Laboratory, University of Minnesota, and University of Missouri.

Xiawei Ou 

Arkansas Children's Nutrition Center, Arkansas Children’s Hospital (ACH) and ACH Research Institute, and University of Arkansas for Medical Sciences, Little Rock, AR

Research Focus: Brain development and nutrition

Diffusion tensor imaging (DTI) permits researchers to non-invasively visualize in three dimensions nerve fibers connecting regions of the human brain. In this image, two important bundles of nerve fibers can be seen: the corticospinal tract, which transmits signals for movement from the brain to the spinal cord, and the corpus callosum, which connects the left and right sides of the brain. The colors indicate the spatial positions of the bundles as reconstructed by BrainVoyager software: left to right orientation (red), back to front orientation (green), and top to bottom orientation (blue). The USDA Agricultural Research Service supports Dr. Ou’s study on the effects of infant diet on brain development.

Jenolyn F. Alexander1, Veronika Kozlovskaya2, Eugenia Kharlampieva2 and Biana Godin*1

1Houston Methodist Research Institute, Houston, TX
2University of Alabama at Birmingham, Birmingham, AL

Research Focus: Targeted drug delivery systems for cancer treatment

In recent years, much research has been conducted on nanoparticles and microcarriers as vehicles for targeted drug delivery. By increasing drug uptake by cancer cells but not healthy ones, this approach could increase the efficacy of treatments and reduce side effects. To optimize delivery, these NIH National Cancer Institute-supported investigators are exploring how the shape of a particle affects its transport through the body and uptake by targeted cells. This overlay image shows breast cancer cells (turquoise and purple) internalizing hollow, cubic microcarriers (gold, enlarged in the upper left hand corner). It was created using two types of imaging technologies—electron scanning microscopy and confocal fluorescence microscopy. 

*Biomedical Engineering Society

Adam Brown* and David Biron*

University of Chicago, Chicago, IL

Research Focus: Behavioral neurobiology

This image depicts a colony of Caenorhabditis elegans nematode worms feeding on bacteria. The worms congregate in patches where bacteria growth is the densest, in this case forming a ring. C. elegans are one of the simplest organisms with a nervous system, making them a valuable model in neurobiology. Mr. Brown is studying how serotonin, which is also present in the human brain, affects food-seeking and foraging behaviors and which specific nerve cells are involved. His research is supported by a training grant from the NIH National Institute of Mental Health

*Genetics Society of America

Heinz Baumann*, Sean T. Glenn†, Mary Kay Ellsworth, and Kenneth W. Gross‡ 

Roswell Park Cancer Institute, Buffalo, NY

Research Focus: Pancreatic cancer

When multiple tumors or cancers have spread throughout the body, distinguishing which cell came from which tumor can be difficult. To overcome this challenge, this research team used “confetti” fluorescent labeling in their mouse model of pancreatic cancer. In this proof of concept image, adult mouse cells were induced to randomly make one of four different fluorescent molecules. The descendants of these cells continue to produce the same color as their parent cell. The NIH National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases fund this research project, which seeks to identify genetic changes that contribute to pancreatic cancer.

*American Society for Biochemistry and Molecular Biology
†Association of Biomolecular Resource Facilities 
‡American Physiological Society

David S. Goodsell

Research Collaboratory for Structural Bioinformatics Protein Data Bank, Piscataway, NJ/La Jolla, CA

Research Focus: Structural biology

This illustration of the Ebola virus shows its seven structural proteins (various shades of blue, green, and magenta), RNA genome (yellow), and membrane (light purple).  The small size of viral genomes greatly limits the number of proteins that can be encoded, so viral proteins often carry out multiple tasks. The Ebola matrix protein (light blue) is a notable example of this phenomenon: it changes shape for each of its different jobs. Through the Protein Data Bank, the three-dimensional structures of Ebola virus proteins are made freely available to investigators around the world to promote research on how to fight this deadly virus.

The image was produced as part of the Protein Data Bank’s Molecule of the Month series, which provides a helpful starting point for exploring this rich database. The Protein Data Bank receives support from the National Science Foundation, National Institutes of Health, and Department of Energy Office of Science to continue to make structural data publicly accessible.

Nathanaёl Prunet1,2, Elliot Meyerowitz1,3*, and Thomas Jack2

1California Institute of Technology, Pasadena, CA
2Dartmouth College, Hanover, NH
3Howard Hughes Medical Institute

Research Focus: Stem cells and flower development

Like most flowering plants, the male organs, or stamens, of Arabidopsis flowers surround a central female organ, or pistil. Precise control of which genes are activated in which cells is essential to the development of these adjacent, yet very distinct, structures. In this image of young Arabidopsis flower buds, the gene SUPERMAN (red) is activated at the boundary between the cells fated to form the male and female parts. SUPERMAN activity prevents the central cells, which will ultimately become the female pistil, from activating the masculinizing gene APETALA3 (green). This research seeks to identify principles of stem cell maintenance and cell specialization, which could inform future studies in agriculture, medicine, and other biological fields. The collaborative team of researchers receives support from the NIH National Institute of General Medical Sciences, the National Science Foundation, and the Department of Energy Office of Science.

* Society for Developmental Biology and Genetics Society of America

Suzana Car*, Maria Hindt, Tracy Punshon, and Mary Lou Guerinot*

Dartmouth College, Hanover, NH

Research Focus: Plant biology and nutrition

The essential micronutrient zinc is vital for the function of more than 300 enzymes. Zinc deficiency affects more than two billion people worldwide and can impair the immune system, gastrointestinal function, and brain development. These researchers study how plants acquire, sequester, and distribute zinc with the goal of finding ways to increase the zinc content of crops. Using synchrotron X-ray fluorescence technology, they created this heat map of zinc levels in an Arabidopsis thaliana plant leaf. The National Science Foundation and the NIH National Institute of General Medical Sciences and National Institute of Environmental Health Sciences provide funding for this research program. The Department of Energy Office of Science funds the National Synchrotron Light Source facility, beamline X27A, which was used to create this image.

*Genetics Society of America 

Shachi Bhatt* and Paul Trainor† 

Stowers Institute for Medical Research, Kansas City, MO

Research Focus: Developmental biology

Blood vessels and nerve cells run in parallel through the body and are dependent upon each other for proper function. They also follow similar early developmental paths, as seen in this image of an embryonic mouse torso. Drs. Bhatt and Trainor are studying these parallel pathways, focusing on a molecule implicated in controlling genes during the early development of blood vessels (gray) and nerve cells (red). Detailed knowledge of normal developmental processes forms a critical foundation for research on birth defects and other diseases affecting the development of these organ systems.

*Genetics Society of America
†American Association of Anatomists, Society of Developmental Biology  

Jessica Ryvlin, Stephanie Lindsey, and Jonathan Butcher*

Cornell University, Ithaca, NY

Research Focus: Heart development

During the embryo development, the formation of congenital heart defects alters blood flow patterns. In this NIH National Heart, Lung, and Blood Institute and National Science Foundation research project, investigators are studying how these patterns change and developing measurement tools with the aim of improving diagnosis of heart defects in human embryos. To observe normal and abnormal heart development in real time, the researchers delicately transfer live chicken embryos from an egg shell to an artificial container. Microsurgical manipulations are used to induce heart defects to model blood flow pattern changes. Images, like this one, are created without any dyes and are instead enhanced using photo manipulation software. The modified images allow researchers to better visualize the developing heart (to the left of the eye) and the network of blood vessels from the heart and throughout the chick embryo.

*American Physiological Society, American Association of Anatomists, and Biomedical Engineering Society

Olivier Duverger* and Maria I. Morasso*

National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD

Research Focus: Tooth enamel development and structure

Enamel is the hardest substance in the body. It protects the surface of the tooth. This scanning electron microscopy image shows the lattice pattern formed by enamel rods, an arrangement that confers strength and flexibility. Genetic mutations affecting enamel formation can result in defects in the thickness, mineralization, and/or lattice pattern of the enamel. This can produce weak teeth prone to decay, which in turn can increase other health risks such as systemic infections and heart disease. These NIH investigators from the Intramural Research Program of the National Institute of Arthritis and Musculoskeletal and Skin Diseases are using mouse models to study how genetic variation affects enamel development and health.

*Society for Developmental Biology 

Mehmet Berkmen and Maria Penil

New England BioLabs, Ipswich, MA

Research Focus: Interactions between bacterial colonies

Dr. Mehmet Berkmen’s laboratory built a unique chamber that allows scientists in the lab to photograph bacteria colonies grown on agar plates for several weeks.

In this video, bacteria painted onto an agar plate grow into an image of a flowering plant. Several different types of bacteria can be seen, including Serratia (red), Bacillus (white), and Nesterenkonia (yellow).

The laboratory receives funding from the National Institutes for Health to develop methods for producing human antibodies in bacteria. The video was created by local artist Maria Penil as a part of the laboratory’s public outreach efforts.

Kimberly Leiken and Elana Harris

Cincinnati Children’s Hospital Medical Center, Cincinnati, OH

Research Focus: Obsessive Compulsive Disorder

This video shows brain activity in an individual with Obsessive Compulsive Disorder who is lying still. Each cube represents brain activity recorded by a sensor in a magnetoencephalography (MEG) helmet, and the different colors indicate activity level (red highest, blue lowest). The researchers used MEG and other neuroimaging technologies to assess treatment responses in individuals with Obsessive Compulsive Disorder. This NIH National Institute of Mental Health-supported study also explores whether there is a relationship between symptom severity and aberrant MEG measurements.