This FASEB SRC is designed to highlight the major advances in science and integrate different topics, which are part of an extremely fast-moving and exciting field of research. The biological scope and the mechanisms of action of DNA and RNA molecules, which have roles in dosage compensation, imprinting, enhancer function and transcriptional regulation, have a great impact in health and diseases, including aging and cancer.
A key reason for the increasing interest in chromatin and transcription is the appreciation that regulation of chromatin organization and transcription is the fundamental cornerstone for establishing gene expression patterns that determine cell state and fate. Researchers studying embryonic stem cells, organism development, diseases (e.g. cancer) have discovered a common interest in elucidating the mechanisms that govern gene expression. Moreover, there has been a recent explosion of activity in the fields of RNA epigenetics and non-coding RNAs, which have become integral parts of the field of gene expression. This five-day conference will gather confirmed and junior scientists from academia, biotech, pharma and clinical settings to share ideas and concepts, and create synergy in the following domains:
- transcription and chromatin in gene regulation,
- chromatin complexes,
- DNA and RNA modifications,
- non-coding RNAs,
- stem cells, aging and cancer.
As epigenomic is the emerging tool for studying complex diseases, this conference will highlight the latest technologies and methodologies for studying biological modifications in cells, tissues and organisms and should attract a lot of attention. Indeed, researchers nowadays work on comprehensive, genome-wide datasets across multiple domains and need to be supported by sophisticated technologies. Experts from academia and industry will present their most recent technological developments in different areas of research. This SRC will also highlight “epitranscriptomics” and should attract a whole range of researchers curious to learn the latest advances in this booming area of epigenetics. Scientists using diverse approaches such as molecular biology, cell biology genetics, epigenomics, and biochemistry will come together to discuss their state-of-the-art discoveries. This SRC series has historically brought together scientists involved with diverse systems and strategies, resulting in exciting and synergistic discussions. 2018 will continue to fulfill this role as a forum for the most advanced science in transcription, chromatin and epigenetics. Together with junior and leader speakers, additional oral presentations will be selected from submitted abstracts and there will be opportunity for dynamic and interactive evening poster presentations. Social and recreational activities will provide all registrants an opportunity to mix with senior scientists. Vibrant interactions between established and young investigators at Meet-the-expert sessions, poster sessions, meals, and social activities provide an ideal opportunity for attendees to meet, discuss, and develop new collaborations.