Folic Acid, Vitamin B12, and One-Carbon Metabolism

Conference Summary

One-carbon metabolism and related dietary factors (folic acid and vitamin B12, as well as vitamin B6, choline, riboflavin, methionine, serine, cysteine, and others) play important roles in a vast array of essential physiological functions.  Disruptions of one-carbon metabolism due to dietary, pharmacological, environmental, and genetic factors impact most of the major health issues of our time, including vascular disease, cancer, neurodegenerative disease (Alzheimer’s disease and dementia, Parkinson’s disease), birth defects, and comorbidities associated with obesity and diabetes such as renal disease.  The “Folic Acid, Vitamin B12, and One-Carbon Metabolism” SRC has been meeting every other year since the mid-1980s.  From its inception, the conference has embraced an integrative philosophy that brings together basic researchers, physician scientists, and policy makers to share cutting edge research and to discuss its ramifications for health at both the personal and population levels.  For 2018, in addition to updates on new findings related to the fundamental biochemistry of folates, B12, and one-carbon metabolism, session topics will focus on 1) Vitamin B12 transporters: binders, receptors & chaperones, 2) Oxidative stress, one-carbon metabolism and development, 3) In utero effects of disruption in one-carbon metabolism, 4) One-Carbon metabolism and neurodegenerative disease, 5) Choline – The good, the bad and the ugly, 6) Interactions between pharmacologic agents, xenobiotics and 1C metabolism, 7) Novel aspects of transsulfuration, and 8) The many faces of MTHFR.   Conference attendees can expect thought-provoking oral communications from leaders in the field, stimulating discussions during questions and answers sessions and expanded opportunities for students and post-doctoral trainees to present their work in both oral and poster sessions, as well as formal and informal opportunities to exchange ideas and establish new collaborations.

Important Deadlines:

  • Early bird registration deadline June 4, 2018
  • Last day to register June 24, 2018


  • Two lively poster sessions with awards competitions for graduate students and post-doctoral trainees
  • Short talks which will be selected from the abstract submissions with an emphasis on young investigators
  • Meet the experts! There will be organized lunch opportunities for students, post-docs, and other young investigators to meet with session chairs and other senior investigators

Keynote Speakers

Jesse Gregory, PhD
University of Florida

Asok Antony
Indiana University

Irwin Rosenberg
Tufts University

Abstract Reviewers

Ralph Green
University of California, Davis

Jesse Gregory
University of Florida

Anne Molloy
Trinity College, Dublin

Ebba Nexo
Aarhus University Hospital

Joshua W. Miller
Rutgers University

Barry Shane
University of California, Berkeley

Thomas Olson
University of Oslo

Jean-Louis Guéant
University Hospital Centre of Nancy

Conference Organizers

Ralph Green, MD, PhD
University of California, Davis

Jesse F. Gregory III, PhD
University of Florida

Jean-Louis Guéant
University Hospital Centre of Nancy

Anne Molloy
Trinity College, Dublin

FASEB Conference Staff

Silvy Song, Conference Manager

Contact us

Email: src@faseb.org
Phone: 1.301.634.7010

Date & Location


July 29-August 3, 2018


Atlantica Oak
36 Treasure Drive
Western Shore, Nova Scotia B0J3M0

Transportation & Lodging

Airport Information

The Halifax Stanfield International Airport (YHZ) is approximately 88.6 kms or 1 hour and 10 minutes from the Atlantica Oak Island Resort & Conference Center.

Click the links below for Transportation & Lodging information:

Official Conference Lodging

Atlantica Oak
36 Treasure Drive
Western Shore, Nova Scotia BOJ3MO

If you request a single or a double occupancy room, the registration fee covers 5 nights of lodging (Sunday through Thursday night, checkout Friday morning). A credit card will be required upon check-in for incidental expenses (i.e. in-room movies, room service, etc.)

If you plan to arrive early or stay beyond the conference dates, you must make your own reservations for the extra nights you require. You are responsible for payment upon check-out.

Click here for additional Offsite Lodging.

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