This SRC will focus on biophysical and structural principles explaining molecular mechanisms in membranes and underlying membrane structure and function. Membranes form the defining boundaries of cells and their organelles. Many metabolic and regulatory functions of cells are carried out by membrane proteins including receptors, transporters, ion channels, proteins involved in signal transduction and energy conversion and many more. All these proteins function in the context of lipid bilayers that can bend, segregate components to form specialized protein and lipid clusters, change their shapes, fuse and separate in processes that require highly specialized molecular machines. The basis of membrane protein structure, dynamic transformation and molecular regulation in the context of large and small membrane systems will be discussed. A principal objective is to stimulate cross-pollination of ideas amongst a diverse group of cell biologists, biochemists, physiologists and biophysicists by bringing them together in an intimate setting to share the latest developments in their fields. Program topics include protein and carbohydrate synthesis in the membrane, membrane signaling, G-protein coupled receptors, intracellular vesicle traffic, exo- and endocytosis, virus entry, mechanisms of ion channels and membrane transporters, clustering and shaping of membrane components in immune recognition, and folding of membrane proteins and amyloids. Biologists will learn about cutting edge biophysical techniques of membrane biology and biophysicists will learn about the latest developments in diverse biological fields of membrane systems, including many that are related to human diseases such as membrane signaling in cancer, membrane transport in cardiovascular disease and diabetes, synaptic transmission and amyloid deposition in neurological and neurodegenerative diseases, and entry pathways, antibiotic resistance, and immune response in infectious diseases.
A significant number of submitted abstracts will be selected for short talks. A specific "meet the experts" session and social activities will allow students and postdoctoral researchers to mingle with invited speakers including two Nobel laureates, to exchange ideas, and to formulate new collaborations.
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