Studies on bacteriophage morphogenesis from 1967-77, fission yeast mitosis and chromosome segregation from 1977 to 2010 in Kyoto University and continued to run his lab from 2005 till now in OISTGU. His laboratory in OISTGU focuses on human blood metabolites particularly emphasizing age- and disease-related metabolites, and on the mechanisms of cellular responses upon nutritional starvation using fission yeast as a model. He also continues to study chromosome segregation trying to combine genetics with structural biology and biochemistry.
Elected as foreign member of EMBO, Royal Society of London and National Academy of Sciences USA. Received prizes including the Order of Cultural Merit. His expertise includes: chromosome segregation, G0 quiescence mechanism, human metabolites aging markers