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In the September ASPET Journal Drug Metabolism and Disposition

August 25, 2017
   

This article is featured in the September issue of Drug Metabolism and Disposition available now:

Identification of Flavin-Containing Monooxygenase 5 (FMO5) as a Regulator of Glucose Homeostasis and a Potential Sensor of Gut Bacteria

FMO5 is identified here as a potential novel therapeutic target for obesity and insulin resistance.  Flavin monooxygenase 5 (FMO5) knockout mice gain less weight, store less fat in white adipose tissue, have lower plasma concentrations of glucose and cholesterol, and enhanced whole-body energy expenditure compared to wild type mice.  Here, Scott and provide evidence for FMO5 as a regulator of body weight and of glucose disposal and insulin sensitivity, possibly involving a role as a sensor of the gut microbiota. Read the full article.



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