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Drug Discovery

Drug discovery identifies candidate treatments for disease. A variety of different scientific fields are involved in the process. Whether identified by screening a large number of compounds for a desired effect or synthesized based on knowledge of chemical structure, many of today’s treatments are based on serendipitous exploratory research in the laboratory.

Articles

Hard copies of the Breakthroughs in Bioscience and Horizons in Bioscience series are available upon request. Please include the desired article, quantity and purpose for the publication's use with your inquiry.

 

Cannabis & Chronic Pain: Separating Science from Stigma

Posted on: November 26, 2018

 

 

Cannabis & Chronic Pain: Separating Science from Stigma – Due to its poor reputation, cannabis and cannabinoid research has languished over the past 50 years.  However, as regulations on its use are softened and scientists take a second look at its effect on the pain pathway, researchers verify its potential role in relieving chronic pain. As the opioid crisis ramps up, cannabinoids may be a useful weapon in fighting addiction while reducing pain. Download the PDF here.

 


 

Regenerative Medicine: Advances from the Convergence of Biology & Engineering

Posted on: November 01, 2016

 

 

Throughout history, medical experts have dreamed of healing untreatable wounds, replacing a disfiguring scar with healthy skin, growing replacement lungs in the laboratory, and replacing a leg lost to injury or disease. Today, regenerative medicine has the potential to heal damaged tissues and organs, offering hope for those who have lost organ function due to age, disease, or injuries.  Download the PDF or listen to the podcast below:

 


 

‘Horizons in Bioscience’ Explores Organs-On-a-Chip

Posted on: December 02, 2015

 

 

Organs-on-a-chip:  The Future of Drug Development and Study of Disease - Imagine if, before you ever took a drug, doctors could predict which drug would work best for you, because they already had information on how organs in your body were likely to respond. Organs-on-a-chip research is bringing that day closer. This emerging technology allows scientists to watch the cascade of events that takes place in organs in response to drugs or during disease. Organs-on-chips are 3-D biochips, no bigger than a computer memory stick, that contain living human cells from an organ or tissue. Engineered in layers and channels, substances such as air or blood can be delivered continuously, and the cells can interface with other living tissues as they do in the body.  Download the PDF or listen to the podcast below:

 


 

FASEB Releases Its Newest Publication in the Breakthroughs in Bioscience Series

Posted on: September 08, 2014

 

Individualized Medicine - Individualized medicine, also known as personalized medicine or genomic medicine, is an approach to medical practice that offers customizable diagnosis and treatment of disease based on one’s genetic make-up. Innovations in individualized medicine come from technological advances that make it feasible to decode a person’s genome. In this article, readers will learn how scientists exploring answers to basic questions about microbes, cancer, the immune system, and other biological processes fostered the current genetic revolution in medicine that is helping physicians find the right treatment for the right patient at the right time.  Read more...


 

FASEB Releases New Breakthroughs in Bioscience Article Titled Conquering Cancer With Drugs From Nature's Medicine Cabinet

Posted on: April 23, 2013

 

 

Conquering Cancer with Drugs from Nature's Medicine Cabinet - Despite a four-decade “war on cancer,” this year, 1.5 million Americans will be diagnosed with a form of this broad group of diseases, and a half million will die as a result. Beginning in the late 1930’s - early 1940’s, researchers were inspired by the success in treating infectious diseases with chemicals isolated from microorganisms and other natural products, such as penicillin from a fungus. Could chemicals battle cancer too?  Download the PDF or listen to the podcast below:

 


 

FASEB Releases New Breakthroughs in Bioscience Article Titled "Conquering Pain and Infection With Drugs From Nature's Medicine Cabinet"

Posted on: July 12, 2012

 

 

Conquering Pain and Infection with Drugs from Nature's Medicine Cabinet - Seventy percent of our drugs for pain and infection are either derived from or inspired by natural products of rainforests and other ecosystems. These medicinal compounds have dramatically improved quality of life and significantly extended the human lifespan. Through decades of basic research to identify new drugs and unravel the underlying mechanisms of action, researchers are developing newer, more powerful therapies.  Download the PDF or listen to the podcast below:

 


 

FASEB Breakthroughs In Bioscience Describes Development Of Monoclonal Antibody Therapies

Posted on: January 21, 2010

 

 

Magic Bullets and Monoclonals: An Antibody Tale - Nearly a century of basic discovery in immunology, cell biology, and cancer biology contributed to today's remarkable monoclonal antibody therapies, which are produced through human-mouse cell hybrids.  Read more...

 

 


 

Viruses, Cancer, Warts and All: The HPV Vaccine for Cervical Cancer

Posted on: June 15, 2008

 

Viruses, Cancer, Warts and All: The HPV Vaccine for Cervical Cancer - The understanding that human papillomavirus (HPV) could cause cervical cancer was the result of decades of fundamental research on wart- and cancer-causing viruses, including the virus from which the legend of the jackalope arose, as well as the study of cervical histology.  Read more...
 


 

Science, Serotonin, and Sadness: The Biology of Antidepressants

Posted on: September 15, 2007

 

 

Science, Serotonin, and Sadness: The Biology of Antidepressants -Basic research into the fundamental functions of the brain transformed our understanding of depression into a treatable, biological condition.  Read more...

 

 


 

Breathtaking Discoveries: How Basic Research Led to Treatments for Asthma

Posted on: March 15, 2007

 

Breathtaking Discoveries: How Basic Research Led to Treatments for Asthma - Fundamental research on the underlying causes of asthma has resulted in a greater understanding of this complex condition and the development of improved and diverse treatment options.  Read more...

 

 

Breast Cancer, Tamoxifen & Beyond: Estrogen and Estrogen Receptors

Posted on: January 15, 2006

 

Breast Cancer, Tamoxifen & Beyond: Estrogen and Estrogen Receptors - Sheep and chickens prove important in breast cancer research. Ewes and hens served as crucial animal models in early studies to understand how estrogen worked and how it affected breast tumor development.  Read more...
 


 

Finding Chinks in the Viral Armor: Influenza, AIDS and Antiviral Therapies

Posted on: March 15, 2005

 

Finding Chinks in the Viral Armor: Influenza, AIDS and Antiviral Therapies - New concerns over a global pandemic of avian influenza, similar to that occurring in 1918 are leading to preventative elimination of poultry stocks in Asia. But thanks to scientists studying the fundamentals of how viruses work and how they are structured we now have the tools to combat viruses that cause influenza, polio, AIDS and other viral diseases.  Read more...


 

Cholesterol: From Biochemical Riddle to Blockbuster Drug for Heart Disease

Posted on: January 15, 2005

 

Cholesterol: From Biochemical Riddle to Blockbuster Drug for Heart Disease - Decades of fundamental research on the mysterious and ubiquitous molecule cholesterol led scientists to understand its role in causing atherosclerosis and heart disease.  Read more...

 


 

Bubbles, Babies and Biology: The Story of Surfactant

Posted on: March 15, 2004

 

Bubbles, Babies and Biology: The Story of Surfactant - Pregnant ewes and premature lambs served as crucial animal models in early studies of using steroid treatment to prevent Respiratory Distress Syndrome (RDS).  Read more...

 


 

Clot Busters! - Discovery of Thrombolytic Therapy for Heart & Stroke

Posted on: January 15, 2004

 

Clot Busters! - Discovery of Thrombolytic Therapy for Heart & Stroke - The venom from a Malaysian pit viper contains an anticoagulant drug which is being studied for use in treating stroke patients. This drug improves blood flow by reducing the amount of fibrinogen (clotting protein) in the blood plasma. The saliva from vampire bats serves as the basis for a new candidate for a thrombolytic therapeutic.  Read more...


 

Genetic Research: Mining for Medical Treasures

Posted on: March 15, 2003

 

Genetic Research: Mining for Medical Treasures - "Knock-out" mice, in which specific genes have been inactivated, have been tremendously useful in helping researchers understand the genetic basis of disease. Moreover, "knock out" mice also serve as animal models for human diseases, allowing researchers to develop treatments and diagnostic tests for genetic diseases.  Read more...
 


 

From Viper’s Venom to Drug Design: Treating Hypertension

Posted on: January 15, 2003

 

From Viper’s Venom to Drug Design: Treating Hypertension - In the development of drugs to treat high blood pressure, dogs and rabbits helped scientists understand how the body controls blood pressure. In addition, ACE inhibitors (an anti-hypertensive) were designed based on experiments with snake venom.  Read more...
 


 

Bone Builders: The Discoveries behind Preventing and Treating Osteoporosis

Posted on: September 15, 2001

 

Bone Builders: The Discoveries behind Preventing and Treating Osteoporosis - The discoveries that led to creating of drugs to treat osteoporosis came out of multiple animal studies, including those involving cows, rats and dogs.  Read more...

 


 

Making Anesthesia Safer: Unraveling the Malignant Hyperthermia Puzzle

Posted on: January 15, 2000

 

Making Anesthesia Safer: Unraveling the Malignant Hyperthermia Puzzle - The causes and prevention of malignant hyperthermia, a violent and sometimes deadly reaction to anesthesia, were discovered with help from pigs, who served as perfect models for this sudden onset condition.  Read more...